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Zoloft is well tolerated and effective for the treatment of depression and certain types of anxiety disorders.

Zoloft is FDA approved to treat depression, social anxiety disorder, posttraumatic stress disorder (PTSD), panic disorder, obsessive-compulsive disorder (OCD), and premenstrual dysphoric disorder (PMDD) in adults over age 18. It is also approved for OCD in children and adolescents age 6-17 years.

For more than 15 years, Zoloft has safely and effectively treated millions of people with depression and anxiety. And Zoloft is available in multiple strengths, so your doctor can decide a dose for you.

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Sertraline hydrochloride is a selective serotonin reuptake inhibitor (SSRI) for oral administration. It has a molecular weight of 342.7. Sertraline hydrochloride has the following chemical name: (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride.

Sertraline hydrochloride is a white crystalline powder that is slightly soluble in water and isopropyl alcohol, and sparingly soluble in ethanol.

Sertraline hydrochloride is supplied for oral administration as scored tablets equivalent to 25, 50 and 100 mg of sertraline and the following inactive ingredients: dibasic calcium phosphate dihydrate, D & C Yellow #10 aluminum lake (in 25 mg tablet), FD & C Blue #1 aluminum lake (in 25 mg tablet), FD & C Red #40 aluminum lake (in 25 mg tablet), FD & C Blue #2 aluminum lake (in 50 mg tablet), hydroxypropyl cellulose, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, sodium starch glycolate, synthetic yellow iron oxide (in 100 mg tablet), and titanium dioxide.

Sertraline hydrochloride oral concentrate is available in a multidose 60 mL bottle. Each mL of solution contains sertraline hydrochloride equivalent to 20 mg of sertraline. The solution contains the following inactive ingredients: glycerin, alcohol (12%), menthol, butylated hydroxytoluene (BHT). The oral concentrate must be diluted prior to administration (see PRECAUTIONS, INFORMATION FOR PATIENTS and DOSAGE AND ADMINISTRATION).

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What is Zoloft?

Zoloft is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Zoloft affects chemicals in the brain that may become unbalanced and cause depression, panic, anxiety, or obsessive-compulsive symptoms.

Zoloft is used to treat depression, obsessive-compulsive disorder, panic disorder, anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD).

Zoloft may also be used for purposes other than those listed in this medication guide.
What is the most important information I should know about Zoloft?
Do not take Zoloft together with pimozide (Orap), or a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate). You must wait at least 14 days after stopping an MAOI before you can take Zoloft. After you stop taking Zoloft, you must wait at least 14 days before you start taking an MAOI.

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You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Zoloft is FDA-approved for children with obsessive-compulsive disorder (OCD). It is not approved for treating depression in children. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.
Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. SSRI antidepressants may cause serious or life-threatening lung problems in newborn babies whose mothers take the medication during pregnancy. However, you may have a relapse of depression if you stop taking your antidepressant during pregnancy. If you are planning a pregnancy, or if you become pregnant while taking Zoloft, do not stop taking the medication without first talking to your doctor.

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Xanax XR (alprazolam) is approved for the treatment of panic disorder. The extended-release tablets are contraindicated in patients with known sensitivity to benzodiazepines or with acute narrow-angle glaucoma. The drug is also contraindicated for use with ketoconzole and itraconazole.

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NEWS

WASHINGTON — The Food and Drug Administration has approved the abbreviated new drug application (ANDA) of Mylan Laboratories Inc. to market a generic version of Xanax XR. Pfizer Inc. manufactures the brand name panic-disorder treatment.

Known under its generic name of alprazolam, the brand product had sales of about $100 million for the 12 months ending in June.

Mylan’s extended-release tablets will be available in 0.5-, 1-, 2- and 3-mg strengths.

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The Medical Letter, Xanax XR for panic disorder. 2003;45(1157):43-44.

Therapy for panic disorder often includes benzodiazepines to provide rapid relief of symptoms, used together with antidepressant medications, which can take weeks to become effective. An extended release formulation of the benzodiazepine alprazolam (Xanax XR) is now available.

The Medical Letter consultants found only two published studies that showed extended-release alprazolam is effective. In one of these studies, extended-release

alprazolam was less effective than immediate-release alprazolam or placebo in some measures. In the other study, response rates to placebo were 61%-81%, making drug effectiveness difficult to substantiate. Two 8-week long studies did not show superiority over placebo. Although extended-release alprazolam requires fewer doses per day than immediate-release alprazolam, clinical data showing that this new formulation is more effective to reduce anxiety between doses are not available. Cognitive behavioral therapy and antidepressants are preferred for long-term treatment of panic disorder. Xanax XR may provide immediate symptoms relief, but needs to be stopped as soon as possible to avoid physical or psychological dependence.

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NOVADEL INITIATES HUMAN STUDY OF ALPRAZOLAM LINGUAL SPRAY.

NovaDel Pharma Inc. (AMEX:NVD), Flemmington, N.J., has commenced a pilot pharmacokinetic feasibility study in humans of a lingual spray version of alprazolam, a widely prescribed anti-anxiety medication marketed as Xanax(R) by Pfizer, Inc, and as a generic by several producers.

The drug’s new formulation utilizes NovaDel’s patented lingual spray drug delivery technology.

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Use of alprazolam in premenstrual syndrome - Tips from Other Journals

Alprazolam, a benzodiazepine, has been studied as a possible treatment for the anxiety- and depression-like components of premenstrual syndrome, but the results of these studies have been inconclusive. Schmidt and colleagues performed a randomized, double-blind, placebo-controlled crossover trial of alprazolam in women with prospectively confirmed premenstrual syndrome.

Women were recruited by newspaper advertisements or physician referral. Twenty women completed the study. A diagnosis of premenstrual syndrome was confirmed through the use of daily self-rating symptom checklists. The women were randomized to receive alprazolam or placebo from day 16 of the menstrual cycle until the onset of menses. Over four menstrual cycles, the alprazolam dose was increased from 0.25 mg to 0.75 mg three times a day. The women completed checklists daily and a battery of psychiatric screening questionnaires twice monthly. Results of these measures in placebo and alprazolam months were then compared.

No differences were found in self-rating scores between alprazolam months and placebo months. Results of psychiatric screening also did not differ between treatment and placebo months, except for a statistically, but not clinically significant, improvement in depression scores during alprazolam treatment.

The authors conclude that no uniform improvement in symptoms of premenstrual syndrome occurs in patients receiving alprazolam, although patients with strong depressive symptoms may have some benefit. (Archives of General Psychiatry, June 1993, vol. 50, p. 467)

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Alprazolam is used to treat anxiety and panic disorders. It belongs to a class of medications called benzodiazepines which act on the brain and nerves (central nervous system) to produce a calming effect. It works by enhancing the effects of a certain natural chemical in the body (GABA).
How to use Xanax Oral

Take this medication by mouth as directed by your doctor. Dosage is based on your medical condition and response to therapy.

This medication may cause dependence, especially if it has been used regularly for an extended period of time, or if it has been used in high doses. In such cases, if you suddenly stop this drug, withdrawal reactions including seizures may occur. Report any such reactions to your doctor immediately. When stopping extended, regular treatment with this drug, the dosage should be gradually reduced as directed to help prevent withdrawal reactions. Consult your doctor or pharmacist for more details.

Though it is very unlikely to occur, this medication can also result in abnormal drug-seeking behavior (addiction/habit-forming). Do not increase your dose, take it more frequently, or use it for a longer period of time than prescribed. Properly stop this medication when so directed. This will lessen the chances of becoming addicted.

When used for an extended period, this medication may not work as well and may require different dosing. Talk with your doctor if this medication stops working well.

Inform your doctor if your condition persists or worsens.

What side effects may occur?
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Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Xanax. Your doctor should periodically reassess the need for this drug.

Side effects of Xanax are usually seen at the beginning of treatment and disappear with continued medication. However, if dosage is increased, side effects will be more likely.

* Side effects of Xanax may include:
Decreased libido, drowsiness, fatigue, impaired coordination, memory impairment, speech difficulties, weight changes

* Side effects of Xanax XR may include:
Constipation, decreased libido, depression, drowsiness, fatigue, impaired coordination, memory problems, mental impairment, nausea, sedation, sleepiness, speech difficulties, weight changes

* Side effects due to a rapid decrease in dose or abrupt withdrawal from Xanax or Xanax XR:
Anxiety, blurred vision, decreased concentration, decreased mental clarity, depression, diarrhea, headache, heightened awareness of noise or bright lights, hot flushes, impaired sense of smell, insomnia, loss of appetite, loss of reality, muscle cramps, nervousness, rapid breathing, seizures, tingling sensation, tremor, twitching, weight loss

Why should Xanax not be prescribed?
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If you are sensitive to or have ever had an allergic reaction to Xanax or other tranquilizers, you should not take this medication. Also avoid Xanax while taking the antifungal drugs. Make sure that your doctor is aware of any drug reactions that you have experienced.

Do not take this medication if you have been diagnosed with the eye condition called narrow-angle glaucoma.

Anxiety or tension related to everyday stress usually does not require treatment with Xanax. Discuss your symptoms thoroughly with your doctor.
Special warnings about Xanax
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Xanax may cause you to become drowsy or less alert; therefore, driving or operating dangerous machinery or participating in any hazardous activity that requires full mental alertness is not recommended.

If you are being treated for panic disorder, you may need to take a higher dose of Xanax than for anxiety alone. High doses—more than 4 milligrams a day—of this medication taken for long intervals may cause emotional and physical dependence. It is important that your doctor supervise you carefully when you are using this medication.

As with all anti-anxiety medication, there is a small chance that Xanax could encourage suicidal thoughts or episodes of euphoria known as mania. If you notice any new or unusual symptoms after starting Xanax, call your doctor immediately.

Xanax should be used with caution in elderly or weak patients, and in those with lung disease, alcoholic liver disease, or any disorder that could hinder the elimination of the drug.

See also the How to Use section.

Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious interactions may occur: certain azole antifungals (e.g., itraconazole, ketoconazole), delavirdine, indinavir, sodium oxybate.

If you are currently using any of these medications, tell your doctor or pharmacist before starting alprazolam.

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Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: clozapine, digoxin, disulfiram, kava.

Tell your doctor or pharmacist if you take drugs that affect the removal of alprazolam from your system (CYP 3A4 substrates, inhibitors and inducers) such as: other azole antifungals (e.g., fluconazole, voriconazole), certain anti-depressants (e.g., fluoxetine, fluvoxamine, nefazodone), certain anti-seizure medications (e.g., phenytoin, phenobarbital), cimetidine, macrolide antibiotics (e.g., erythromycin, clarithromycin), rifamycins (e.g., rifampin), ritonavir, St John’s wort.

Tell your doctor or pharmacist if you take drugs that cause drowsiness such as: antihistamines that cause drowsiness (e.g., diphenhydramine), anti-seizure drugs (e.g., carbamazepine), medicine for sleep (e.g., sedatives), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., phenothiazines such as chlorpromazine, tricyclic anti-depressants such as amitriptyline), tranquilizers.

Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain ingredients which cause drowsiness. Ask your pharmacist about the safe use of those products.

Cigarette smoking decreases blood levels of this medication (through liver enzyme induction). Tell your doctor if you smoke or if you have recently stopped smoking because your dose may need to be adjusted.

Do not start or stop any medicine without doctor or pharmacist approval.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.Tags:Where to Buy Xanax

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